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Genetics of Autism Spectrum Disorder: Current Status and Possible Clinical Applications.

ABSTRACT: Autism spectrum disorder (ASD) is one of the most complex behavioral disorders with a strong genetic influence. The objectives of this article are to review the current status of genetic research in ASD, and to provide information regarding the potential candidate genes, mutations, and genetic loci possibly related to pathogenesis in ASD. Investigations on monogenic causes of ASD, candidate genes among common variants, rare de novo mutations, and copy number variations are reviewed. The current possible clinical applications of the genetic knowledge and their future possibilities are highlighted.

SUBMITTER: Yoo H

PROVIDER: S-EPMC4688327 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Genetics of Autism Spectrum Disorder: Current Status and Possible Clinical Applications.

Yoo Heejeong H

Experimental neurobiology 20151216 4

Autism spectrum disorder (ASD) is one of the most complex behavioral disorders with a strong genetic influence. The objectives of this article are to review the current status of genetic research in ASD, and to provide information regarding the potential candidate genes, mutations, and genetic loci possibly related to pathogenesis in ASD. Investigations on monogenic causes of ASD, candidate genes among common variants, rare de novo mutations, and copy number variations are reviewed. The current ...[more]

PMID: 26713075

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