Ontology highlight
ABSTRACT:
SUBMITTER: El Hayek L
PROVIDER: S-EPMC7755391 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
eLife 20201222
Autism spectrum disorder (ASD) is a constellation of neurodevelopmental disorders with high phenotypic and genetic heterogeneity, complicating the discovery of causative genes. Through a forward genetics approach selecting for defective vocalization in mice, we identified <i>Kdm5a</i> as a candidate ASD gene. To validate our discovery, we generated a <i>Kdm5a</i> knockout mouse model (<i>Kdm5a</i><sup>-/-</sup>) and confirmed that inactivating <i>Kdm5a</i> disrupts vocalization. In addition, <i> ...[more]