Ontology highlight
ABSTRACT:
SUBMITTER: Song J
PROVIDER: S-EPMC4689315 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Song Jikui J Rechkoblit Olga O Bestor Timothy H TH Patel Dinshaw J DJ
Science (New York, N.Y.) 20101216 6020
Maintenance of genomic methylation patterns is mediated primarily by DNA methyltransferase-1 (DNMT1). We have solved structures of mouse and human DNMT1 composed of CXXC, tandem bromo-adjacent homology (BAH1/2), and methyltransferase domains bound to DNA-containing unmethylated CpG sites. The CXXC specifically binds to unmethylated CpG dinucleotide and positions the CXXC-BAH1 linker between the DNA and the active site of DNMT1, preventing de novo methylation. In addition, a loop projecting from ...[more]