Ontology highlight
ABSTRACT:
SUBMITTER: Song J
PROVIDER: S-EPMC4693633 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Song Jikui J Teplova Marianna M Ishibe-Murakami Satoko S Patel Dinshaw J DJ
Science (New York, N.Y.) 20120201 6069
DNMT1, the major maintenance DNA methyltransferase in animals, helps to regulate gene expression, genome imprinting, and X-chromosome inactivation. We report on the crystal structure of a productive covalent mouse DNMT1(731-1602)-DNA complex containing a central hemimethylated CpG site. The methyl group of methylcytosine is positioned within a shallow hydrophobic concave surface, whereas the cytosine on the target strand is looped out and covalently anchored within the catalytic pocket. The DNA ...[more]