Ontology highlight
ABSTRACT:
SUBMITTER: Dai L
PROVIDER: S-EPMC4692142 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Blood 20151103 26
Kaposi sarcoma-associated herpesvirus (KSHV) is a principal causative agent of primary effusion lymphoma (PEL) with a poor prognosis in immunocompromised patients. However, it still lacks effective treatment which urgently requires the identification of novel therapeutic targets for PEL. Here, we report that the hepatocyte growth factor (HGF)/c-MET pathway is highly activated by KSHV in vitro and in vivo. The selective c-MET inhibitor, PF-2341066, can induce PEL apoptosis through cell cycle arre ...[more]