Regulation of Cellular Identity in Cancer.
Ontology highlight
ABSTRACT:
SUBMITTER: Roy N
PROVIDER: S-EPMC4692359 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Publications
Regulation of Cellular Identity in Cancer.
Roy Nilotpal N Hebrok Matthias M
Developmental cell 20151201 6
Neoplastic transformation requires changes in cellular identity. Emerging evidence increasingly points to cellular reprogramming, a process during which fully differentiated and functional cells lose aspects of their identity while gaining progenitor characteristics, as a critical early step during cancer initiation. This cell identity crisis persists even at the malignant stage in certain cancers, suggesting that reactivation of progenitor functions supports tumorigenicity. Here, we review rece ...[more]
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