Browse
Submit Data
Databases
API
Help

Dataset Information

14 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Seroepidemiology of Human Enterovirus 71 Infection among Children, Cambodia.

ABSTRACT: Enterovirus 71 is reported to have emerged in Cambodia in 2012; at least 54 children with severe encephalitis died during that outbreak. We used serum samples collected during 2000-2011 to show that the virus had been widespread in the country for at least a decade before the 2012 outbreak.

SUBMITTER: Horwood PF

PROVIDER: S-EPMC4696711 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Similar Datasets

Epidemiology and seroepidemiology of human enterovirus 71 among Thai populations.

Project description: Not available

| S-EPMC3937078 | biostudies-literature

Seroepidemiology and molecular epidemiology of enterovirus 71 in Russia.

Project description: Not available

| S-EPMC4018281 | biostudies-literature

Seroepidemiology of enterovirus D68 infection in China.

Project description: Not available

| S-EPMC5520479 | biostudies-literature

Immunity to avirulent enterovirus 71 and coxsackie A16 virus protects against enterovirus 71 infection in mice.

Project description: Not available

| S-EPMC2045469 | biostudies-literature

Mild, moderate and severe enterovirus 71 (EV71) isolates infection in human PBMCs

Project description:Hand, foot and mouth disease (HFMD), caused by enterovirus 71 (EV71), presents mild to severe disease, and sometimes fatal neurological and respiratory manifestations. However, reasons for the severe pathogenesis remain undefined. To investigate this, infection and viral kinetics of EV71 isolates from clinical disease (mild, moderate and severe) from Sarawak, Malaysia, were characterized in human rhabdomyosarcoma (RD), neuroblastoma (SH-SY5Y) and peripheral blood mononuclear cells (PBMCs). High resolution transcriptomics was used to decipher EV71-host interactions in PBMCs. Ingenuity analyses revealed similar pathways triggered by all EV71 isolates, although the extent of activation varied. Importantly, several pathways were found to be specific to the severe isolate, including triggering receptor expressed on myeloid cells 1 (TREM-1) signaling. Depletion of TREM-1 in EV71-infected PBMCs with peptide LP17 resulted in decreased levels of pro-inflammatory genes, and reduced viral loads for the moderate and severe isolates. Mechanistically, this is the first report describing the transcriptome profiles during EV71 infections in primary human cells, and the involvement of TREM-1 in the severe disease pathogenesis, thus providing new insights for future treatment targets.

2020-03-16 | GSE135964 | GEO

Caveolar endocytosis is required for human PSGL-1-mediated enterovirus 71 infection.

Project description: Not available

| S-EPMC3754029 | biostudies-literature

Human enterovirus 71 epidemics: what's next?

Project description: Not available

| S-EPMC3772321 | biostudies-literature

Crystal structure of human enterovirus 71.

Project description: Not available

| S-EPMC3448362 | biostudies-literature

Enterovirus 71 seroepidemiology in Taiwan in 2017 and comparison of those rates in 1997, 1999 and 2007.

Project description: Not available