Ontology highlight
ABSTRACT:
SUBMITTER: Yamauchi Y
PROVIDER: S-EPMC4697804 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Yamauchi Yasuhiro Y Riel Jonathan M JM Ruthig Victor V Ward Monika A MA
PLoS genetics 20151231 12
Spermatogenesis is a key developmental process allowing for a formation of a mature male gamete. During its final phase, spermiogenesis, haploid round spermatids undergo cellular differentiation into spermatozoa, which involves extensive restructuring of cell morphology, DNA, and epigenome. Using mouse models with abrogated Y chromosome gene complements and Y-derived transgene we identified Y chromosome encoded Zfy2 as the gene responsible for sperm formation and function. In the presence of a Z ...[more]