Ontology highlight
ABSTRACT:
SUBMITTER: Blaisdell A
PROVIDER: S-EPMC4698345 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Blaisdell Adam A Crequer Amandine A Columbus Devin D Daikoku Takiko T Mittal Khush K Dey Sudhansu K SK Erlebacher Adrian A
Cancer cell 20151201 6
Polymorphonuclear neutrophils (PMNs) are largely considered to foster cancer development despite wielding an arsenal of cytotoxic agents. Using a mouse model of PTEN-deficient uterine cancer, we describe a surprising inhibitory role for PMNs in epithelial carcinogenesis. By inducing tumor cell detachment from the basement membrane, PMNs impeded early-stage tumor growth and retarded malignant progression. Unexpectedly, PMN recruitment and tumor growth control occurred independently of lymphocytes ...[more]