Unknown

Dataset Information

0

Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells.


ABSTRACT: Polymorphonuclear neutrophils (PMNs) are largely considered to foster cancer development despite wielding an arsenal of cytotoxic agents. Using a mouse model of PTEN-deficient uterine cancer, we describe a surprising inhibitory role for PMNs in epithelial carcinogenesis. By inducing tumor cell detachment from the basement membrane, PMNs impeded early-stage tumor growth and retarded malignant progression. Unexpectedly, PMN recruitment and tumor growth control occurred independently of lymphocytes and cellular senescence and instead ensued as part of the tumor's intrinsic inflammatory response to hypoxia. In humans, a PMN gene signature correlated with improved survival in several cancer subtypes, including PTEN-deficient uterine cancer. These findings provide insight into tumor-associated PMNs and reveal a context-specific capacity for PMNs to directly combat tumorigenesis.

SUBMITTER: Blaisdell A 

PROVIDER: S-EPMC4698345 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells.

Blaisdell Adam A   Crequer Amandine A   Columbus Devin D   Daikoku Takiko T   Mittal Khush K   Dey Sudhansu K SK   Erlebacher Adrian A  

Cancer cell 20151201 6


Polymorphonuclear neutrophils (PMNs) are largely considered to foster cancer development despite wielding an arsenal of cytotoxic agents. Using a mouse model of PTEN-deficient uterine cancer, we describe a surprising inhibitory role for PMNs in epithelial carcinogenesis. By inducing tumor cell detachment from the basement membrane, PMNs impeded early-stage tumor growth and retarded malignant progression. Unexpectedly, PMN recruitment and tumor growth control occurred independently of lymphocytes  ...[more]

Similar Datasets

2015-09-29 | GSE73541 | GEO
| S-EPMC6142213 | biostudies-literature
| S-EPMC10824957 | biostudies-literature
| S-EPMC5509478 | biostudies-literature
| 13392 | ecrin-mdr-crc
| S-EPMC3525572 | biostudies-literature
| S-EPMC9330475 | biostudies-literature
| S-EPMC6949488 | biostudies-literature
| S-EPMC4942661 | biostudies-literature
| S-EPMC6731176 | biostudies-literature