Ontology highlight
ABSTRACT:
SUBMITTER: Takagi A
PROVIDER: S-EPMC4702170 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Takagi Ayano A Kume Shinji S Kondo Motoyuki M Nakazawa Jun J Chin-Kanasaki Masami M Araki Hisazumi H Araki Shin-ichi S Koya Daisuke D Haneda Masakazu M Chano Tokuhiro T Matsusaka Taiji T Nagao Kenji K Adachi Yusuke Y Chan Lawrence L Maegawa Hiroshi H Uzu Takashi T
Scientific reports 20160106
Autophagy is an intracellular degradation system activated, across species, by starvation. Although accumulating evidence has shown that mammalian autophagy is involved in pathogenesis of several modern diseases, its physiological role to combat starvation has not been fully clarified. In this study, we analysed starvation-induced gluconeogenesis and ketogenesis in mouse strains lacking autophagy in liver, skeletal muscle or kidney. Autophagy-deficiency in any tissue had no effect on gluconeogen ...[more]