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Optical coherence tomography reflects brain atrophy in multiple sclerosis: A four-year study.

ABSTRACT: The aim of this work was to determine whether atrophy of specific retinal layers and brain substructures are associated over time, in order to further validate the utility of optical coherence tomography (OCT) as an indicator of neuronal tissue damage in patients with multiple sclerosis (MS).Cirrus high-definition OCT (including automated macular segmentation) was performed in 107 MS patients biannually (median follow-up: 46 months). Three-Tesla magnetic resonance imaging brain scans (including brain-substructure volumetrics) were performed annually. Individual-specific rates of change in retinal and brain measures (estimated with linear regression) were correlated, adjusting for age, sex, disease duration, and optic neuritis (ON) history.Rates of ganglion cell?+?inner plexiform layer (GCIP) and whole-brain (r?=?0.45; p?

SUBMITTER: Saidha S 

PROVIDER: S-EPMC4703093 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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<h4>Objective</h4>The aim of this work was to determine whether atrophy of specific retinal layers and brain substructures are associated over time, in order to further validate the utility of optical coherence tomography (OCT) as an indicator of neuronal tissue damage in patients with multiple sclerosis (MS).<h4>Methods</h4>Cirrus high-definition OCT (including automated macular segmentation) was performed in 107 MS patients biannually (median follow-up: 46 months). Three-Tesla magnetic resonan  ...[more]

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