Ontology highlight
ABSTRACT:
SUBMITTER: Shin JH
PROVIDER: S-EPMC470727 | biostudies-literature | 2004 Jun
REPOSITORIES: biostudies-literature
Shin J H JH Gardel M L ML Mahadevan L L Matsudaira P P Weitz D A DA
Proceedings of the National Academy of Sciences of the United States of America 20040621 26
The organization of individual actin filaments into higher-order structures is controlled by actin-binding proteins (ABPs). Although the biological significance of the ABPs is well documented, little is known about how bundling and cross-linking quantitatively affect the microstructure and mechanical properties of actin networks. Here we quantify the effect of the ABP scruin on actin networks by using imaging techniques, cosedimentation assays, multiparticle tracking, and bulk rheology. We show ...[more]