Ontology highlight
ABSTRACT:
SUBMITTER: Guan F
PROVIDER: S-EPMC4708990 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Guan Feng F Ding Youming Y Zhang Yemin Y Zhou Yu Y Li Mingxin M Wang Changhua C
PloS one 20160111 1
Previous studies have evidenced that the anticancer potential of curcumin (diferuloylmethane), a main yellow bioactive compound from plant turmeric was mediated by interfering with PI3K/Akt signaling. However, the underlying molecular mechanism is still poorly understood. This study experimentally revealed that curcumin treatment reduced Akt protein expression in a dose- and time-dependent manner in MDA-MB-231 breast cancer cells, along with an activation of autophagy and suppression of ubiquiti ...[more]