St. John's Wort Suppresses Growth in Triple-Negative Breast Cancer Cell Line MDA-MB-231 by Inducing Prodeath Autophagy and Apoptosis.
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SUBMITTER: You M
PROVIDER: S-EPMC7602992 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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St. John's Wort Suppresses Growth in Triple-Negative Breast Cancer Cell Line MDA-MB-231 by Inducing Prodeath Autophagy and Apoptosis.
You Mikyoung M Lee Young-Hyun YH Kim Hwa-Jin HJ Kook Ji Hyun JH Kim Hyeon-A HA
Nutrients 20201017 10
The rational regulation of programmed cell death by means of autophagy and apoptosis has been considered a potential treatment strategy for cancer. We demonstrated the inhibitory effect of St. John's Wort (SJW) on growth in the triple-negative breast cancer (TNBC) cell line and xenografted mice and its target mechanism concerning autophagic and apoptotic cell death. SJW ethanol extract (SJWE) inhibited proliferation in a dose-dependent manner. SJWE treatment dramatically increased autophagy flux ...[more]
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