The Coadministration of N-Acetylcysteine Ameliorates the Effects of Arsenic Trioxide on the Male Mouse Genital System.
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ABSTRACT:
SUBMITTER: da Silva RF
PROVIDER: S-EPMC4709715 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
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The Coadministration of N-Acetylcysteine Ameliorates the Effects of Arsenic Trioxide on the Male Mouse Genital System.
da Silva Raquel Frenedoso RF Borges Cibele dos Santos Cdos S Villela E Silva Patrícia P Missassi Gabriela G Kiguti Luiz Ricardo Almeida LR Pupo André Sampaio AS Barbosa Junior Fernando F Anselmo-Franci Janete Aparecida JA Kempinas Wilma De Grava Wde G
Oxidative medicine and cellular longevity 20151229
Arsenic trioxide (As2O3) has shown effectiveness in treatment of leukemia but is also associated with reproductive toxicity. Since remediation with N-acetylcysteine (NAC) may mitigate the adverse effects caused by exposure, we assessed the effects of As2O3 and its potential reversibility after exposure cessation or coadministration of NAC. Animals received 0.3 or 3.0 mg/Kg/day of As2O3 subcutaneously and 40 mM of NAC in tap water. As2O3 treatment impaired spermatogenesis and sperm motility and d ...[more]
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