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Biodegradable Block Copolymer-Tannic Acid Glue.

ABSTRACT: Bioadhesives are becoming an essential and important ingredient in medical science. Despite numerous reports, developing adhesive materials that combine strong adhesion, biocompatibility, and biodegradation remains a challenging task. Here, we present a biocompatible yet biodegradable block copolymer-based waterborne superglue that leads to an application of follicle-free hair transplantation. Our design strategy bridges self-assembled, temperature-sensitive block copolymer nanostructures with tannic acid as a sticky and biodegradable polyphenolic compound. The formulation further uniquely offers step-by-step increases in adhesion strength via heating-cooling cycles. Combining the modular design with the thermal treating process enhances the mechanical properties up to 5 orders of magnitude compared to the homopolymer formulation. This study opens a new direction in bioadhesive formulation strategies utilizing block copolymer nanotechnology for systematic and synergistic control of the material's properties.

SUBMITTER: Park J

PROVIDER: S-EPMC9516699 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Biodegradable Block Copolymer-Tannic Acid Glue.

Park Jongmin J Park Eunsook E Choi Siyoung Q SQ Wu Jingxian J Park Jihye J Lee Hyeonju H Kim Hyungjun H Lee Haeshin H Seo Myungeun M

JACS Au 20220822 9

Bioadhesives are becoming an essential and important ingredient in medical science. Despite numerous reports, developing adhesive materials that combine strong adhesion, biocompatibility, and biodegradation remains a challenging task. Here, we present a biocompatible yet biodegradable block copolymer-based waterborne superglue that leads to an application of follicle-free hair transplantation. Our design strategy bridges self-assembled, temperature-sensitive block copolymer nanostructures with t ...[more]

PMID: 36186559

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