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Synthesis and Self-Assembly of Bundle-Forming ?-Helical Peptide-Dendron Hybrids.

ABSTRACT: Dendronized helix bundle assemblies combine the sequence diversity and folding properties of proteins with the tailored physical properties of dendrimers. Assembly of peptide-dendron hybrids into ?-helical bundles encapsulates the helix bundle motif in a dendritic sheath that will allow the functional, protein-like domain to be transplanted to nonbiological environments. A bioorthogonal graft-to synthetic strategy for preparing helix bundle-forming peptide-dendron hybrids is described herein for hybrids 1a, 1b, and 2. Titration experiments monitored by circular dichroism spectroscopy support our self-assembly model for how the peptide-dendron hybrids self-assemble into ?-helical bundles with the dendrons on outside of the bundle.

SUBMITTER: Marine JE

PROVIDER: S-EPMC4710556 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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Synthesis and Self-Assembly of Bundle-Forming α-Helical Peptide-Dendron Hybrids.

Marine Jeannette E JE Song Shuang S Liang Xiaoli X Rudick Jonathan G JG

Biomacromolecules 20151223 1

Dendronized helix bundle assemblies combine the sequence diversity and folding properties of proteins with the tailored physical properties of dendrimers. Assembly of peptide-dendron hybrids into α-helical bundles encapsulates the helix bundle motif in a dendritic sheath that will allow the functional, protein-like domain to be transplanted to nonbiological environments. A bioorthogonal graft-to synthetic strategy for preparing helix bundle-forming peptide-dendron hybrids is described herein for ...[more]

PMID: 26674475

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