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Association of MMP-2 gene haplotypes with thoracic aortic dissection in chinese han population.


ABSTRACT: Thoracic aortic dissection (TAD) is the most common life-threatening disorder, and MMP-2 is involved in TAD pathogenesis. Our purpose is to systematically evaluate the association of the MMP-2 gene with TAD risk in Chinese Han population.In our case-control study, we recruited 755 unrelated participants: 315 case participants with TAD and 440 controls. Twenty-two tag SNPs were selected from MMP-2 gene and were genotyped. Genotype data were analyzed by logistic regression.Although we did not find any significant association for MMP-2 SNPs using single-marker analysis, we identified many windows with haplotype frequencies significantly different between case participants and control participants using a variable-sized sliding-window strategy. In particular, the most significant association was shown by a 2-SNP window consisting of rs2241145 and rs9928731 (omnibus test: asymptotic Pasym = 7.48 × 10 (-5) and empirical Pemp = 0.001867). There were two protective haplotypes: CT (Pasym = 0.00303; odds ratio [OR], 0.403) and GC (Pasym = 0.000976; OR, 0.448).MMP-2 haplotypes are associated with genetic susceptibility to thoracic aortic dissection in Chinese Han population.

SUBMITTER: Liu O 

PROVIDER: S-EPMC4712614 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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Association of MMP-2 gene haplotypes with thoracic aortic dissection in chinese han population.

Liu Ou O   Li Jiachen J   Xin Yi Y   Qin Yanwen Y   Li Haiyang H   Gong Ming M   Liu Yuyong Y   Wang Xiaolong X   Li Jianrong J   Zhang Hongjia H  

BMC cardiovascular disorders 20160114


<h4>Background</h4>Thoracic aortic dissection (TAD) is the most common life-threatening disorder, and MMP-2 is involved in TAD pathogenesis. Our purpose is to systematically evaluate the association of the MMP-2 gene with TAD risk in Chinese Han population.<h4>Methods</h4>In our case-control study, we recruited 755 unrelated participants: 315 case participants with TAD and 440 controls. Twenty-two tag SNPs were selected from MMP-2 gene and were genotyped. Genotype data were analyzed by logistic  ...[more]

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