Ontology highlight
ABSTRACT:
SUBMITTER: Lin H
PROVIDER: S-EPMC4713350 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Lin Hui H Jackson Glenn A GA Lu Yuan Y Drenkhahn Sara K SK Brownstein Korey J KJ Starkey Nicholas J NJ Lamberson William R WR Fritsche Kevin L KL Mossine Valeri V VV Besch-Williford Cynthia L CL Folk William R WR Zhang Yong Y Lubahn Dennis B DB
Cell biology international 20151006 2
Sutherlandia frutescens is a medicinal plant, traditionally used to treat various types of human diseases, including cancer. Previous studies of several botanicals link suppression of prostate cancer growth with inhibition of the Gli/hedgehog (Gli/Hh) signaling pathway. Here we hypothesized the anti-cancer effect of S. frutescens was linked to its inhibition of the Gli/Hh signaling in prostate cancer. We found a dose- and time-dependent growth inhibition in human prostate cancer cells, PC3 and L ...[more]