Ontology highlight
ABSTRACT:
SUBMITTER: Xie H
PROVIDER: S-EPMC6562674 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Xie Hao H Paradise Brooke D BD Ma Wen Wee WW Fernandez-Zapico Martin E ME
Cells 20190429 5
The Hedgehog/GLI signaling pathway plays an important role in normal embryonic tissue development and has been implicated in the pathogenesis of various human cancers. In this review article, we summarize pre-clinical evidence supporting the suitability of targeting this signaling pathway in cancers. We review agents blocking both the ligand-dependent and ligand-independent cascades, and discuss the clinical evidence, which has led to the FDA approval of Hedgehog receptor Smoothened inhibitors, ...[more]