Ontology highlight
ABSTRACT:
SUBMITTER: Zou C
PROVIDER: S-EPMC4713725 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Acta neuropathologica 20160102 2
To successfully treat Alzheimer's disease (AD), pathophysiological events in preclinical stages need to be identified. Preclinical AD refers to the stages that exhibit amyloid deposition in the brain but have normal cognitive function, which are replicated in young adult APPswe/PS1deltaE9 (deltaE9) mice. By long-term in vivo two-photon microscopy, we demonstrate impaired adaptive spine plasticity in these transgenic mice illustrated by their failure to increase dendritic spine density and form n ...[more]