Unknown

Dataset Information

0

Neuroinflammation impairs adaptive structural plasticity of dendritic spines in a preclinical model of Alzheimer's disease.


ABSTRACT: To successfully treat Alzheimer's disease (AD), pathophysiological events in preclinical stages need to be identified. Preclinical AD refers to the stages that exhibit amyloid deposition in the brain but have normal cognitive function, which are replicated in young adult APPswe/PS1deltaE9 (deltaE9) mice. By long-term in vivo two-photon microscopy, we demonstrate impaired adaptive spine plasticity in these transgenic mice illustrated by their failure to increase dendritic spine density and form novel neural connections when housed in enriched environment (EE). Decrease of amyloid plaques by reducing BACE1 activity restores the gain of spine density upon EE in deltaE9 mice, but not the remodeling of neural networks. On the other hand, anti-inflammatory treatment with pioglitazone or interleukin 1 receptor antagonist in deltaE9 mice successfully rescues the impairments in increasing spine density and remodeling of neural networks during EE. Our data suggest that neuroinflammation disrupts experience-dependent structural plasticity of dendritic spines in preclinical stages of AD.

SUBMITTER: Zou C 

PROVIDER: S-EPMC4713725 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Neuroinflammation impairs adaptive structural plasticity of dendritic spines in a preclinical model of Alzheimer's disease.

Zou Chengyu C   Shi Yuan Y   Ohli Jasmin J   Schüller Ulrich U   Dorostkar Mario M MM   Herms Jochen J  

Acta neuropathologica 20160102 2


To successfully treat Alzheimer's disease (AD), pathophysiological events in preclinical stages need to be identified. Preclinical AD refers to the stages that exhibit amyloid deposition in the brain but have normal cognitive function, which are replicated in young adult APPswe/PS1deltaE9 (deltaE9) mice. By long-term in vivo two-photon microscopy, we demonstrate impaired adaptive spine plasticity in these transgenic mice illustrated by their failure to increase dendritic spine density and form n  ...[more]

Similar Datasets

| S-EPMC5018790 | biostudies-literature
| S-EPMC3166652 | biostudies-literature
| S-EPMC4514647 | biostudies-literature
| S-EPMC4218863 | biostudies-literature
| S-EPMC3216532 | biostudies-literature
| S-EPMC6042854 | biostudies-literature
| S-EPMC2118058 | biostudies-literature
| S-EPMC5222721 | biostudies-literature
| S-EPMC7952241 | biostudies-literature
| S-EPMC4225776 | biostudies-literature