Ontology highlight
ABSTRACT:
SUBMITTER: Fang J
PROVIDER: S-EPMC4715643 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Fang Jinxu J Xiao Liang L Joo Kye-Il KI Liu Yarong Y Zhang Chupei C Liu Shuanglong S Conti Peter S PS Li Zibo Z Wang Pin P
International journal of cancer 20150914 4
Fibroblast activation protein (FAP) is highly expressed in the tumor-associated fibroblasts (TAFs) of most human epithelial cancers. FAP plays a critical role in tumorigenesis and cancer progression, which makes it a promising target for novel anticancer therapy. However, mere abrogation of FAP enzymatic activity by small molecules is not very effective in inhibiting tumor growth. In this study, we have evaluated a novel immune-based approach to specifically deplete FAP-expressing TAFs in a mous ...[more]