Dataset Information
Association study of TREM2 polymorphism rs75932628 with leucoaraiosis or Parkinson's disease in the Han Chinese population.
Ontology highlight
ABSTRACT: Objectives
The previously reported functional mutation rs75932628-T (p.R47H) in the triggering receptor expressed on myeloid cells 2 (TREM2) is a genetic risk factor for Alzheimer's disease, Parkinson's disease (PD) and frontotemporal dementia, in European populations. This study aims to assess the genetic association of the variant rs75932628-T with PD and leucoaraiosis (LA) in a Han Chinese population.Setting
This population-based study was conducted in China by Xiamen University and its affiliated hospital.Participants
308 patients with LA, 342 patients with PD and 198 healthy blood donors were recruited from the First Affiliated Hospital of Xiamen University.Outcome measures
Genotyping was performed by molecular beacon real-time PCR and Sanger sequencing.Results
None of our participants carried the rs75932628-T mutation.Conclusions
Our results corroborate and extend previous findings, concluding that the variant rs75932628-T (p.R47H) in TREM2 is not a risk factor for LA or PD in the Han Chinese population.
SUBMITTER: Li Z
PROVIDER: S-EPMC4716257 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
Association study of TREM2 polymorphism rs75932628 with leucoaraiosis or Parkinson's disease in the Han Chinese population.
BMJ open 20160112 1
<h4>Objectives</h4>The previously reported functional mutation rs75932628-T (p.R47H) in the triggering receptor expressed on myeloid cells 2 (TREM2) is a genetic risk factor for Alzheimer's disease, Parkinson's disease (PD) and frontotemporal dementia, in European populations. This study aims to assess the genetic association of the variant rs75932628-T with PD and leucoaraiosis (LA) in a Han Chinese population.<h4>Setting</h4>This population-based study was conducted in China by Xiamen Universi ...[more]
