Ontology highlight
ABSTRACT:
SUBMITTER: Jia L
PROVIDER: S-EPMC4718674 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Jia Lifeng L Song Qi Q Zhou Chenyang C Li Xiaoming X Pi Lihong L Ma Xiuru X Li Hui H Lu Xiuying X Shen Yupeng Y
PloS one 20160119 1
Developing drugs that can effectively block STAT3 activation may serve as one of the most promising strategy for cancer treatment. Currently, there is no putative STAT3 inhibitor that can be safely and effectively used in clinic. In the present study, we investigated the potential of dihydroartemisinin (DHA) as a putative STAT3 inhibitor and its antitumor activities in head and neck squamous cell carcinoma (HNSCC). The inhibitory effects of DHA on STAT3 activation along with its underlying mecha ...[more]