Ontology highlight
ABSTRACT:
SUBMITTER: Kumase F
PROVIDER: S-EPMC4723067 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Kumase Fumiaki F Takeuchi Kimio K Morizane Yuki Y Suzuki Jun J Matsumoto Hidetaka H Kataoka Keiko K Al-Moujahed Ahmad A Maidana Daniel E DE Miller Joan W JW Vavvas Demetrios G DG
PloS one 20160122 1
C-C chemokine receptor 2 (Ccr2) is a key pro-inflammatory marker of classic (M1) macrophage activation. Although Ccr2 is known to be expressed both constitutively and inductively, the full regulatory mechanism of its expression remains unclear. AMP-activated protein kinase (AMPK) is not only a master regulator of energy homeostasis but also a central regulator of inflammation. In this study, we sought to assess AMPK's role in regulating RAW264.7 macrophage Ccr2 protein levels in resting (M0) or ...[more]