Identification of a small molecule HIV-1 inhibitor that targets the capsid hexamer.
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ABSTRACT:
SUBMITTER: Xu JP
PROVIDER: S-EPMC4728034 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
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Identification of a small molecule HIV-1 inhibitor that targets the capsid hexamer.
Xu Jimmy P JP Branson Jeffrey D JD Lawrence Rae R Cocklin Simon S
Bioorganic & medicinal chemistry letters 20151225 3
The HIV-1 CA protein is an attractive therapeutic target for the development of new antivirals. An inter-protomer pocket within the hexamer configuration of the CA, which is a binding site for key host dependency factors, is an especially appealing region for small molecule targeting. Using a field-based pharmacophore derived from an inhibitor known to interact with this region, coupled to biochemical and biological assessment, we have identified a new compound that inhibits HIV-1 infection and ...[more]
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