Ontology highlight
ABSTRACT:
SUBMITTER: Kobayakawa T
PROVIDER: S-EPMC7913237 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Kobayakawa Takuya T Yokoyama Masaru M Tsuji Kohei K Fujino Masayuki M Kurakami Masaki M Boku Sayaka S Nakayama Miyuki M Kaneko Moemi M Ohashi Nami N Kotani Osamu O Murakami Tsutomu T Sato Hironori H Tamamura Hirokazu H
Biomolecules 20210203 2
The capsid of human immunodeficiency virus type 1 (HIV-1) is a shell that encloses viral RNA and is highly conserved among many strains of the virus. It forms a conical structure by assembling oligomers of capsid (CA) proteins. CA dysfunction is expected to be an important target of suppression of HIV-1 replication, and it is important to understand a new mechanism that could lead to the CA dysfunction. A drug targeting CA however, has not been developed to date. Hydrophobic interactions between ...[more]