Ontology highlight
ABSTRACT:
SUBMITTER: Manville CM
PROVIDER: S-EPMC4728365 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Manville Catriona M CM Smith Kayleigh K Sondka Zbyslaw Z Rance Holly H Cockell Simon S Cowell Ian G IG Lee Ka Cheong KC Morris Nicholas J NJ Padget Kay K Jackson Graham H GH Austin Caroline A CA
Biology open 20151012 11
We report the whole genome ChIP seq for human TOP2B from MCF7 cells. Using three different peak calling methods, regions of binding were identified in the presence or absence of the nuclear hormone estradiol, as TOP2B has been reported to play a role in ligand-induced transcription. TOP2B peaks were found across the whole genome, 50% of the peaks fell either within a gene or within 5 kb of a transcription start site. TOP2B peaks coincident with gene promoters were less frequently associated with ...[more]