Unknown

Dataset Information

0

Rich diversity and potency of skin antioxidant peptides revealed a novel molecular basis for high-altitude adaptation of amphibians.


ABSTRACT: Elucidating the mechanisms of high-altitude adaptation is an important research area in modern biology. To date, however, knowledge has been limited to the genetic mechanisms of adaptation to the lower oxygen and temperature levels prevalent at high altitudes, with adaptation to UV radiation largely neglected. Furthermore, few proteomic or peptidomic analyses of these factors have been performed. In this study, the molecular adaptation of high-altitude Odorrana andersonii and cavernicolous O. wuchuanensis to elevated UV radiation was investigated. Compared with O. wuchuanensis, O. andersonii exhibited greater diversity and free radical scavenging potentiality of skin antioxidant peptides to cope with UV radiation. This implied that O. andersonii evolved a much more complicated and powerful skin antioxidant peptide system to survive high-altitude UV levels. Our results provided valuable peptidomic clues for understanding the novel molecular basis for adaptation to high elevation habitats.

SUBMITTER: Yang X 

PROVIDER: S-EPMC4728494 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Rich diversity and potency of skin antioxidant peptides revealed a novel molecular basis for high-altitude adaptation of amphibians.

Yang Xinwang X   Wang Ying Y   Zhang Yue Y   Lee Wen-Hui WH   Zhang Yun Y  

Scientific reports 20160127


Elucidating the mechanisms of high-altitude adaptation is an important research area in modern biology. To date, however, knowledge has been limited to the genetic mechanisms of adaptation to the lower oxygen and temperature levels prevalent at high altitudes, with adaptation to UV radiation largely neglected. Furthermore, few proteomic or peptidomic analyses of these factors have been performed. In this study, the molecular adaptation of high-altitude Odorrana andersonii and cavernicolous O. wu  ...[more]

Similar Datasets

| S-EPMC5474778 | biostudies-literature
| S-EPMC6359409 | biostudies-literature
| S-EPMC5048413 | biostudies-literature
| S-EPMC1839143 | biostudies-literature
| S-EPMC8571627 | biostudies-literature
2014-02-20 | E-GEOD-55175 | biostudies-arrayexpress
| S-EPMC6685962 | biostudies-literature
| S-EPMC5792094 | biostudies-other
| S-EPMC6726534 | biostudies-literature
| S-EPMC5739465 | biostudies-literature