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Isonitrile alkylations: a rapid route to imidazo[1,5-a]pyridines.


ABSTRACT: Metalated arylmethylisonitriles readily add to 2-chloropyridines to afford imidazo[1,5-a]pyridines. Analogous additions to imidoyl chlorides and a chloroquinoline provide imidazoles and an imidazo[1,5-a]quinolone which, like imidazo[1,5-a]pyridines, are valuable heterocycles for pharmaceutical synthesis.

SUBMITTER: Li Y 

PROVIDER: S-EPMC4729585 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Isonitrile alkylations: a rapid route to imidazo[1,5-a]pyridines.

Li Yajun Y   Chao Allen A   Fleming Fraser F FF  

Chemical communications (Cambridge, England) 20160201 10


Metalated arylmethylisonitriles readily add to 2-chloropyridines to afford imidazo[1,5-a]pyridines. Analogous additions to imidoyl chlorides and a chloroquinoline provide imidazoles and an imidazo[1,5-a]quinolone which, like imidazo[1,5-a]pyridines, are valuable heterocycles for pharmaceutical synthesis. ...[more]

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