Isonitrile alkylations: a rapid route to imidazo[1,5-a]pyridines.
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ABSTRACT: Metalated arylmethylisonitriles readily add to 2-chloropyridines to afford imidazo[1,5-a]pyridines. Analogous additions to imidoyl chlorides and a chloroquinoline provide imidazoles and an imidazo[1,5-a]quinolone which, like imidazo[1,5-a]pyridines, are valuable heterocycles for pharmaceutical synthesis.
SUBMITTER: Li Y
PROVIDER: S-EPMC4729585 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
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