Ontology highlight
ABSTRACT:
SUBMITTER: Raimondi L
PROVIDER: S-EPMC4736225 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
BioMed research international 20160104
Multiple myeloma (MM) is a hematologic malignancy of differentiated plasma cells that accumulate in the bone marrow, where a complex microenvironment made by different cell types supports proliferation, survival, and drug resistance of tumor cells. MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression at posttranscriptional level. Emerging evidence indicates that miRNAs are aberrantly expressed or functionally deregulated in MM cells as the result of multiple genetic or epig ...[more]