Ontology highlight
ABSTRACT:
SUBMITTER: Teske KA
PROVIDER: S-EPMC4737989 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Teske Kelly A KA Bogart Jonathon W JW Sanchez Luis M LM Yu Olivia B OB Preston Joshua V JV Cook James M JM Silvaggi Nicholas R NR Bikle Daniel D DD Arnold Leggy A LA
European journal of medicinal chemistry 20160106
A systematic study with phase 1 and phase 2 metabolites of cholesterol and vitamin D was conducted to determine whether their biological activity is mediated by the vitamin D receptor (VDR). The investigation necessitated the development of novel synthetic routes for lithocholic acid (LCA) glucuronides (Gluc). Biochemical and cell-based assays were used to demonstrate that hydroxylated LCA analogs were not able to bind VDR. This excludes VDR from mediating their biological and pharmacological ac ...[more]