Ontology highlight
ABSTRACT:
SUBMITTER: Gilbert DC
PROVIDER: S-EPMC4740930 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Gilbert Duncan C DC Al-Saadi Reem R Thway Khin K Chandler Ian I Berney Daniel D Gabe Rhian R Stenning Sally P SP Sweet Joan J Huddart Robert R Shipley Janet M JM
Clinical cancer research : an official journal of the American Association for Cancer Research 20151009 5
<h4>Purpose</h4>Up to 50% of patients diagnosed with stage I nonseminomatous germ cell tumors (NSGCTs) harbor occult metastases. Patients are managed by surveillance with chemotherapy at relapse or adjuvant treatment up front. Late toxicities from chemotherapy are increasingly recognized. Based on a potential biologic role in germ cells/tumors and pilot data, our aim was to evaluate tumor expression of the chemokine CXCL12 alongside previously proposed markers as clinically useful biomarkers of ...[more]