Ontology highlight
ABSTRACT:
SUBMITTER: Chen KS
PROVIDER: S-EPMC5932259 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Chen Kenneth S KS Fustino Nicholas J NJ Shukla Abhay A AA Stroup Emily K EK Budhipramono Albert A Ateek Christina C Stuart Sarai H SH Yamaguchi Kiyoshi K Kapur Payal P Frazier A Lindsay AL Lum Lawrence L Looijenga Leendert H J LHJ Laetsch Theodore W TW Rakheja Dinesh D Amatruda James F JF
Molecular cancer therapeutics 20180226 5
Germ cell tumors (GCT) are malignant tumors that arise from pluripotent embryonic germ cells and occur in children and young adults. GCTs are treated with cisplatin-based regimens which, while overall effective, fail to cure all patients and cause significant adverse late effects. The seminoma and nonseminoma forms of GCT exhibit distinct differentiation states, clinical behavior, and response to treatment; however, the molecular mechanisms of GCT differentiation are not fully understood. We tes ...[more]