Ontology highlight
ABSTRACT:
SUBMITTER: Hoyos V
PROVIDER: S-EPMC4817892 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Hoyos Valentina V Del Bufalo Francesca F Yagyu Shigeki S Ando Miki M Dotti Gianpietro G Suzuki Masataka M Bouchier-Hayes Lisa L Alemany Ramon R Brenner Malcolm K MK
Molecular therapy : the journal of the American Society of Gene Therapy 20150618 9
Oncolytic adenoviruses (OAdV) represent a promising strategy for cancer therapy. Despite their activity in preclinical models, to date the clinical efficacy remains confined to minor responses after intratumor injection. To overcome these limitations, we developed an alternative approach using the combination of the OAdv ICOVIR15 with a replication incompetent adenoviral vector carrying the suicide gene of inducible Caspase 9 (Ad.iC9), both of which are delivered by mesenchymal stromal cells (MS ...[more]