Inflammation in acute CNS injury: a focus on the role of substance P.
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ABSTRACT:
SUBMITTER: Corrigan F
PROVIDER: S-EPMC4742293 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Inflammation in acute CNS injury: a focus on the role of substance P.
Corrigan F F Vink R R Turner R J RJ
British journal of pharmacology 20150512 4
Recently, a number of reports have shown that neurogenic inflammation may play a role in the secondary injury response following acute injury to the CNS, including traumatic brain injury (TBI) and stroke. In particular substance P (SP) release appears to be critically involved. Specifically, the expression of the neuropeptide SP is increased in acute CNS injury, with the magnitude of SP release being related to both the frequency and magnitude of the insult. SP release is associated with an incr ...[more]
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