Ontology highlight
ABSTRACT:
SUBMITTER: Speckmann T
PROVIDER: S-EPMC4742737 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Speckmann Thilo T Sabatini Paul V PV Nian Cuilan C Smith Riley G RG Lynn Francis C FC
The Journal of biological chemistry 20151209 6
Cytosolic calcium influx activates signaling pathways known to support pancreatic beta cell function and survival by modulating gene expression. Impaired calcium signaling leads to decreased beta cell mass and diabetes. To appreciate the causes of these cytotoxic perturbations, a more detailed understanding of the relevant signaling pathways and their respective gene targets is required. In this study, we examined the calcium-induced expression of the cytoprotective beta cell transcription facto ...[more]