Ontology highlight
ABSTRACT:
SUBMITTER: Mostafavi S
PROVIDER: S-EPMC4743492 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Mostafavi Sara S Yoshida Hideyuki H Moodley Devapregasan D LeBoité Hugo H Rothamel Katherine K Raj Towfique T Ye Chun Jimmie CJ Chevrier Nicolas N Zhang Shen-Ying SY Feng Ting T Lee Mark M Casanova Jean-Laurent JL Clark James D JD Hegen Martin M Telliez Jean-Baptiste JB Hacohen Nir N De Jager Philip L PL Regev Aviv A Mathis Diane D Benoist Christophe C
Cell 20160101 3
Type 1 interferon (IFN) is a key mediator of organismal responses to pathogens, eliciting prototypical "interferon signature genes" that encode antiviral and inflammatory mediators. For a global view of IFN signatures and regulatory pathways, we performed gene expression and chromatin analyses of the IFN-induced response across a range of immunocyte lineages. These distinguished ISGs by cell-type specificity, kinetics, and sensitivity to tonic IFN and revealed underlying changes in chromatin con ...[more]