Ontology highlight
ABSTRACT:
SUBMITTER: Chen C
PROVIDER: S-EPMC4745067 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
We studied a core cancer gene regulatory network motif to uncover possible source of cancer heterogeneity from epigenetic sources. When the time scale of the protein regulation to the gene is faster compared to the protein synthesis and degradation (adiabatic regime), normal state, cancer state and an intermediate premalignant state emerge. Due to the epigenetics such as DNA methylation and histone remodification, the time scale of the protein regulation to the gene can be slower or comparable t ...[more]