Ontology highlight
ABSTRACT:
SUBMITTER: Gyuris A
PROVIDER: S-EPMC6604862 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Gyuris Aron A Navarrete-Perea Jose J Jo Ala A Cristea Simona S Zhou Shuang S Fraser Kyle K Wei Zhiyun Z Krichevsky Anna M AM Weissleder Ralph R Lee Hakho H Gygi Steve P SP Charest Al A
Cell reports 20190601 13
Cancer extracellular vesicles (EVs) are highly heterogeneous, which impedes our understanding of their function as intercellular communication agents and biomarkers. To deconstruct this heterogeneity, we analyzed extracellular RNAs (exRNAs) and extracellular proteins (exPTNs) from size fractionation of large, medium, and small EVs and ribonucleoprotein complexes (RNPs) from mouse glioblastoma cells by RNA sequencing and quantitative proteomics. mRNA from medium-sized EVs most closely reflects th ...[more]