Ontology highlight
ABSTRACT:
SUBMITTER: Stewart K
PROVIDER: S-EPMC4747337 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Stewart Katherine K Gaitan Yaned Y Shafer Maxwell E R ME Aoudjit Lamine L Hu Di D Sharma Richa R Tremblay Mathieu M Ishii Hidetaka H Marcotte Michael M Stanga Daniela D Tang You Chi YC Boualia Sami Kamel SK Nguyen Alana H T AH Takano Tomoko T Lamarche-Vane Nathalie N Vidal Silvia S Bouchard Maxime M
PLoS genetics 20160209 2
Rho family GTPases act as molecular switches regulating actin cytoskeleton dynamics. Attenuation of their signaling capacity is provided by GTPase-activating proteins (GAPs), including p190A, that promote the intrinsic GTPase activity of Rho proteins. In the current study we have performed a small-scale ENU mutagenesis screen and identified a novel loss of function allele of the p190A gene Arhgap35, which introduces a Leu1396 to Gln substitution in the GAP domain. This results in decreased GAP a ...[more]