Ontology highlight
ABSTRACT:
SUBMITTER: Lee J
PROVIDER: S-EPMC4751086 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Lee Juhyeon J Oh Kyoung-Jin KJ Lee Dasom D Kim Bo Yeon BY Choi Joon Sig JS Ku Bonsu B Kim Seung Jun SJ
PloS one 20160211 2
EGFR is a key player in cell proliferation and survival signaling, and its sorting into MVBs for eventual lysosomal degradation is controlled by the coordination of multiple ESCRT complexes on the endosomal membrane. HD-PTP is a cytosolic protein tyrosine phosphatase, and is associated with EGFR trafficking by interacting with the ESCRT-0 protein STAM2 and the ESCRT-III protein CHMP4B via its N-terminal Bro1 domain. Intriguingly, the homologous domain of two other human Bro1 domain-containing pr ...[more]