Ontology highlight
ABSTRACT:
SUBMITTER: Gahloth D
PROVIDER: S-EPMC5567221 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Gahloth Deepankar D Heaven Graham G Jowitt Thomas A TA Mould A Paul AP Bella Jordi J Baldock Clair C Woodman Philip P Tabernero Lydia L
Scientific reports 20170822 1
HD-PTP is a tumour suppressor phosphatase that controls endocytosis, down-regulation of mitogenic receptors and cell migration. Central to its role is the specific recruitment of critical endosomal sorting complexes required for transport (ESCRTs). However, the molecular mechanisms that enable HD-PTP to regulate ESCRT function are unknown. We have characterised the molecular architecture of the entire ESCRT binding region of HD-PTP using small angle X-ray scattering and hydrodynamic analyses. We ...[more]