Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC4753514 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Wang Xuefeng X Rahil Zainab Z Li Isaac T S IT Chowdhury Farhan F Leckband Deborah E DE Chemla Yann R YR Ha Taekjip T
Scientific reports 20160215
Recently a variety of molecular force sensors have been developed to study cellular forces acting through single mechano-sensitive receptors. A common strategy adopted is to attach ligand molecules on a surface through engineered molecular tethers which report cell-exerted tension on receptor-ligand bonds. This approach generally requires chemical conjugation of the ligand to the force reporting tether which can be time-consuming and labor-intensive. Moreover, ligand-tether conjugation can sever ...[more]