Ontology highlight
ABSTRACT:
SUBMITTER: Montagner A
PROVIDER: S-EPMC4754633 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Montagner Alexandra A Korecka Agata A Polizzi Arnaud A Lippi Yannick Y Blum Yuna Y Canlet Cécile C Tremblay-Franco Marie M Gautier-Stein Amandine A Burcelin Rémy R Yen Yi-Chun YC Je Hyunsoo Shawn HS Al-Asmakh Maha M Mithieux Gilles G Arulampalam Velmurugesan V Lagarrigue Sandrine S Guillou Hervé H Pettersson Sven S Wahli Walter W
Scientific reports 20160216
The liver is a key organ of metabolic homeostasis with functions that oscillate in response to food intake. Although liver and gut microbiome crosstalk has been reported, microbiome-mediated effects on peripheral circadian clocks and their output genes are less well known. Here, we report that germ-free (GF) mice display altered daily oscillation of clock gene expression with a concomitant change in the expression of clock output regulators. Mice exposed to microbes typically exhibit characteriz ...[more]