Ontology highlight
ABSTRACT:
SUBMITTER: DasGupta S
PROVIDER: S-EPMC4755583 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
DasGupta Saurja S Shelke Sandip A SA Li Nan-sheng NS Piccirilli Joseph A JA
Chemical communications (Cambridge, England) 20150501 43
Spinach RNA aptamer contains a G-quadruplex motif that serves as a platform for binding and fluorescence activation of a GFP-like fluorophore. Here we show that Pb(2+) induces formation of Spinach's G-quadruplex and activates fluorescence with high selectivity and sensitivity. This device establishes the first example of an RNA-based sensor that provides a simple and inexpensive tool for Pb(2+) detection. ...[more]