Ontology highlight
ABSTRACT:
SUBMITTER: Rodrigo Albors A
PROVIDER: S-EPMC4755742 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Rodrigo Albors Aida A Tazaki Akira A Rost Fabian F Nowoshilow Sergej S Chara Osvaldo O Tanaka Elly M EM
eLife 20151114
Axolotls are uniquely able to mobilize neural stem cells to regenerate all missing regions of the spinal cord. How a neural stem cell under homeostasis converts after injury to a highly regenerative cell remains unknown. Here, we show that during regeneration, axolotl neural stem cells repress neurogenic genes and reactivate a transcriptional program similar to embryonic neuroepithelial cells. This dedifferentiation includes the acquisition of rapid cell cycles, the switch from neurogenic to pro ...[more]