Ontology highlight
ABSTRACT:
SUBMITTER: Le Nours J
PROVIDER: S-EPMC4756352 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Nature communications 20160215
Crucial to Natural Killer T (NKT) cell function is the interaction between their T-cell receptor (TCR) and CD1d-antigen complex. However, the diversity of the NKT cell repertoire and the ensuing interactions with CD1d-antigen remain unclear. We describe an atypical population of CD1d-α-galactosylceramide (α-GalCer)-reactive human NKT cells that differ markedly from the prototypical TRAV10-TRAJ18-TRBV25-1(+) type I NKT cell repertoire. These cells express a range of TCR α- and β-chains that show ...[more]