Ontology highlight
ABSTRACT:
SUBMITTER: Lopez-Sagaseta J
PROVIDER: S-EPMC3343337 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
The EMBO journal 20120306 8
Invariant Natural Killer T (iNKT) cells use highly restricted αβ T cell receptors (TCRs) to probe the repertoire of lipids presented by CD1d molecules. Here, we describe our studies of lysophosphatidylcholine (LPC) presentation by human CD1d and its recognition by a native, LPC-specific iNKT TCR. Human CD1d presenting LPC adopts an altered conformation from that of CD1d presenting glycolipid antigens, with a shifted α1 helix resulting in an open A' pocket. Binding of the iNKT TCR requires a 7-Å ...[more]