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A genome-wide association study identifies a genomic region for the polycerate phenotype in sheep (Ovis aries).


ABSTRACT: Horns are a cranial appendage found exclusively in Bovidae, and play important roles in accessing resources and mates. In sheep (Ovies aries), horns vary from polled to six-horned, and human have been selecting polled animals in farming and breeding. Here, we conducted a genome-wide association study on 24 two-horned versus 22 four-horned phenotypes in a native Chinese breed of Sishui Fur sheep. Together with linkage disequilibrium (LD) analyses and haplotype-based association tests, we identified a genomic region comprising 132.0-133.1 Mb on chromosome 2 that contained the top 10 SNPs (including 4 significant SNPs) and 5 most significant haplotypes associated with the polycerate phenotype. In humans and mice, this genomic region contains the HOXD gene cluster and adjacent functional genes EVX2 and KIAA1715, which have a close association with the formation of limbs and genital buds. Our results provide new insights into the genetic basis underlying variable numbers of horns and represent a new resource for use in sheep genetics and breeding.

SUBMITTER: Ren X 

PROVIDER: S-EPMC4756668 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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A genome-wide association study identifies a genomic region for the polycerate phenotype in sheep (Ovis aries).

Ren Xue X   Yang Guang-Li GL   Peng Wei-Feng WF   Zhao Yong-Xin YX   Zhang Min M   Chen Ze-Hui ZH   Wu Fu-An FA   Kantanen Juha J   Shen Min M   Li Meng-Hua MH  

Scientific reports 20160217


Horns are a cranial appendage found exclusively in Bovidae, and play important roles in accessing resources and mates. In sheep (Ovies aries), horns vary from polled to six-horned, and human have been selecting polled animals in farming and breeding. Here, we conducted a genome-wide association study on 24 two-horned versus 22 four-horned phenotypes in a native Chinese breed of Sishui Fur sheep. Together with linkage disequilibrium (LD) analyses and haplotype-based association tests, we identifi  ...[more]

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